Two sample MR report

Telomere_length against aseg rh intensity choroid-plexus

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0577855	0.1206535	0.6369323
Weighted median	23	0.0838834	0.0593318	0.1574204
Inverse variance weighted	23	0.0772702	0.0476591	0.1049514
Simple mode	23	0.1876458	0.1261778	0.1511673
Weighted mode	23	-0.0465783	0.0979186	0.6389890

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	30.93811	21	0.0746942
Inverse variance weighted	33.11675	22	0.0602503

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0082924	0.0068191	0.2374538

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0011233	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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