Two sample MR report

Telomere_length against aseg rh intensity VentralDC

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1559877	0.1156157	0.1916442
Weighted median	23	-0.0894358	0.0647317	0.1670825
Inverse variance weighted	23	-0.0489240	0.0478790	0.3068637
Simple mode	23	0.1290623	0.1439290	0.3795828
Weighted mode	23	-0.1433088	0.1046134	0.1845413

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	28.40813	21	0.1289514
Inverse variance weighted	33.42332	22	0.0561622

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0125815	0.0065343	0.0678224

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010609	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8