Two sample MR report

Telomere_length against aseg rh intensity Thalamus-Proper

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0425854	0.1125468	0.7089467
Weighted median	23	-0.1201773	0.0629216	0.0561392
Inverse variance weighted	23	-0.1025159	0.0449317	0.0225133
Simple mode	23	-0.2203821	0.1058855	0.0492510
Weighted mode	23	-0.1692994	0.0772644	0.0393202

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	26.91934	21	0.1735389
Inverse variance weighted	29.43405	22	0.1328809

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0089092	0.0063609	0.1759303

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.001103	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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