Two sample MR report

Telomere_length against aseg rh intensity Putamen

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.2227834	0.1393374	0.1247863
Weighted median	23	0.0864887	0.0559474	0.1221305
Inverse variance weighted	23	0.0944753	0.0544506	0.0827291
Simple mode	23	0.0919848	0.1061039	0.3953371
Weighted mode	23	0.0964547	0.0631178	0.1407216

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	41.26143	21	0.0052040
Inverse variance weighted	43.22779	22	0.0044236

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0078781	0.0078751	0.3285109

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.001489	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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