Two sample MR report

Telomere_length against aseg rh intensity Pallidum

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0350474	0.1521316	0.8200296
Weighted median	23	-0.0809054	0.0616386	0.1893253
Inverse variance weighted	23	-0.0089995	0.0582184	0.8771516
Simple mode	23	0.0086674	0.1063157	0.9357616
Weighted mode	23	-0.0538328	0.0788356	0.5018307

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	49.18588	21	0.0004730
Inverse variance weighted	49.41761	22	0.0007026

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0027045	0.0085982	0.7562141

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0014985	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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