Two sample MR report

Telomere_length against aseg rh intensity Lateral-Ventricle

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0125520	0.1148776	0.9140307
Weighted median	23	0.0404450	0.0589392	0.4925772
Inverse variance weighted	23	0.0364784	0.0440833	0.4079604
Simple mode	23	0.0885526	0.1055075	0.4103281
Weighted mode	23	0.0474786	0.0772321	0.5450251

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	28.04626	21	0.1388441
Inverse variance weighted	28.33340	22	0.1648936

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0030105	0.0064927	0.6476513

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008853	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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