Two sample MR report

Telomere_length against aseg rh intensity Inf-Lat-Vent

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0296675	0.1243043	0.8136764
Weighted median	23	0.0321556	0.0569692	0.5724563
Inverse variance weighted	23	0.0348938	0.0474602	0.4622045
Simple mode	23	0.0305927	0.0859098	0.7251563
Weighted mode	23	0.0189518	0.0615317	0.7609789

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	32.83702	21	0.0480559
Inverse variance weighted	32.84028	22	0.0641561

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0003209	0.0070254	0.9640001

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010196	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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