Two sample MR report

Telomere_length against aseg rh intensity Hippocampus

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0685816	0.1317861	0.6082277
Weighted median	23	0.0674267	0.0615893	0.2736136
Inverse variance weighted	23	0.0804386	0.0503260	0.1099650
Simple mode	23	0.3280964	0.1364856	0.0250853
Weighted mode	23	0.0516522	0.0758987	0.5032614

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	36.90984	21	0.0172397
Inverse variance weighted	36.92663	22	0.0240981

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.000728	0.0074482	0.923063

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0012489	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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