Two sample MR report

Telomere_length against aseg rh intensity Cerebellum-Cortex

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2104930	0.1438274	0.1581358
Weighted median	23	-0.0838889	0.0555429	0.1309553
Inverse variance weighted	23	0.0191458	0.0587139	0.7443596
Simple mode	23	-0.0132364	0.0848913	0.8775163
Weighted mode	23	-0.0842145	0.0555670	0.1438708

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	43.96319	21	0.0023640
Inverse variance weighted	50.26177	22	0.0005405

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0140996	0.0081287	0.0974768

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0015302	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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