Two sample MR report

Telomere_length against aseg rh intensity Caudate

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1069066	0.0994052	0.2943694
Weighted median	23	0.0823496	0.0583676	0.1582802
Inverse variance weighted	23	0.0735246	0.0388451	0.0583890
Simple mode	23	0.0006661	0.1034524	0.9949207
Weighted mode	23	0.0716941	0.0742335	0.3446460

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	20.83654	21	0.4689652
Inverse variance weighted	20.96963	22	0.5226155

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0020496	0.0056182	0.7188902

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000744	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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