Two sample MR report

Telomere_length against aseg rh intensity Amygdala

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0913129	0.1407554	0.5235415
Weighted median	23	0.0018677	0.0584505	0.9745085
Inverse variance weighted	23	0.0628575	0.0538006	0.2426688
Simple mode	23	0.0120806	0.0981823	0.9031903
Weighted mode	23	-0.0112482	0.0555355	0.8413552

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	42.10479	21	0.0040820
Inverse variance weighted	42.20150	22	0.0059089

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0017471	0.0079551	0.8282839

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.001358	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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