Two sample MR report

Telomere_length against aseg rh intensity Accumbens-area

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0655592	0.1127653	0.5671745
Weighted median	23	0.0387193	0.0613880	0.5282170
Inverse variance weighted	23	0.0248662	0.0432100	0.5649718
Simple mode	23	0.0018503	0.1032037	0.9858574
Weighted mode	23	0.0394735	0.0744767	0.6014132

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	27.02390	21	0.1700634
Inverse variance weighted	27.22168	22	0.2029274

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0024986	0.0063733	0.6989807

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008373	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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