Two sample MR report

Telomere_length against aseg lh volume vessel

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1348397	0.0994063	0.1893613
Weighted median	23	0.0370870	0.0535964	0.4889576
Inverse variance weighted	23	-0.0106384	0.0401054	0.7908076
Simple mode	23	0.0097113	0.0824403	0.9072963
Weighted mode	23	0.0535241	0.0611165	0.3906167

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	20.92255	21	0.4636830
Inverse variance weighted	23.45029	22	0.3766885

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0089323	0.0056182	0.1268031

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007128	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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