Two sample MR report

Telomere_length against aseg lh volume choroid-plexus

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1075739	0.1132027	0.3527811
Weighted median	23	0.0402815	0.0597475	0.5001866
Inverse variance weighted	23	0.0227496	0.0438964	0.6042794
Simple mode	23	0.0158778	0.1003429	0.8757145
Weighted mode	23	0.0972513	0.0777603	0.2241993

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	27.23455	21	0.1632237
Inverse variance weighted	28.09395	22	0.1725885

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0052082	0.006398	0.4247564

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008617	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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