Two sample MR report

Telomere_length against aseg lh volume VentralDC

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0006470	0.1320526	0.9961372
Weighted median	23	-0.0720844	0.0571382	0.2071002
Inverse variance weighted	23	-0.0335115	0.0505109	0.5070414
Simple mode	23	-0.0092870	0.0987837	0.9259496
Weighted mode	23	-0.0652994	0.0590243	0.2805421

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	37.05910	21	0.0165730
Inverse variance weighted	37.19846	22	0.0224964

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0020973	0.0074632	0.7814466

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0011497	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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