Two sample MR report

Telomere_length against aseg lh volume Thalamus-Proper

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0713629	0.1037931	0.4992607
Weighted median	23	0.0095422	0.0570104	0.8670740
Inverse variance weighted	23	0.0427018	0.0397121	0.2822479
Simple mode	23	0.0961158	0.1057356	0.3731906
Weighted mode	23	-0.0064078	0.0744192	0.9321630

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	22.89433	21	0.3496385
Inverse variance weighted	22.99244	22	0.4021567

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0017598	0.0058662	0.7671339

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007333	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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