Two sample MR report

Telomere_length against aseg lh volume Putamen

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0405606	0.1360351	0.7685092
Weighted median	23	-0.0163794	0.0609222	0.7880389
Inverse variance weighted	23	-0.0586571	0.0527075	0.2657596
Simple mode	23	0.0089489	0.1027179	0.9313631
Weighted mode	23	0.0046379	0.0824101	0.9556284

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	39.32876	21	0.0089644
Inverse variance weighted	40.50456	22	0.0094335

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0060919	0.0076883	0.4370129

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0012963	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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