Two sample MR report

Telomere_length against aseg lh volume Pallidum

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1213666	0.1429528	0.4054572
Weighted median	23	-0.0140058	0.0617799	0.8206532
Inverse variance weighted	23	-0.0192507	0.0560421	0.7312196
Simple mode	23	-0.0377683	0.1319293	0.7773448
Weighted mode	23	-0.0116886	0.0750969	0.8777305

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	43.43018	21	0.0027691
Inverse variance weighted	45.79190	22	0.0021031

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0086338	0.0080793	0.297366

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0013949	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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