Two sample MR report

Telomere_length against aseg lh volume Lateral-Ventricle

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0397207	0.1180510	0.7398547
Weighted median	23	0.0450384	0.0558997	0.4204157
Inverse variance weighted	23	-0.0078061	0.0451633	0.8627751
Simple mode	23	0.0689576	0.0913577	0.4583684
Weighted mode	23	0.0497889	0.0658768	0.4577931

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	29.61684	21	0.0999623
Inverse variance weighted	29.73850	22	0.1249601

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0019596	0.006672	0.7718709

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009023	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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