Two sample MR report

Telomere_length against aseg lh volume Inf-Lat-Vent

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0360254	0.1135010	0.7540733
Weighted median	23	0.0819093	0.0597021	0.1700737
Inverse variance weighted	23	0.0253228	0.0433443	0.5590688
Simple mode	23	-0.0846616	0.1032863	0.4211914
Weighted mode	23	0.0418577	0.0718873	0.5663057

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	27.37753	21	0.1587037
Inverse variance weighted	27.39121	22	0.1967433

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0006571	0.0064148	0.9193793

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008429	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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