Two sample MR report

Telomere_length against aseg lh volume Hippocampus

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1272625	0.1195311	0.2991098
Weighted median	23	-0.0276187	0.0606582	0.6488810
Inverse variance weighted	23	-0.0180848	0.0474943	0.7033672
Simple mode	23	-0.1011995	0.1293104	0.4421996
Weighted mode	23	-0.0468586	0.0754183	0.5407761

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	30.36447	21	0.0849050
Inverse variance weighted	32.88774	22	0.0634704

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0089243	0.0067556	0.2007098

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010031	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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