Two sample MR report

Telomere_length against aseg lh volume Cortex

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.3041206	0.1260668	0.0250784
Weighted median	23	-0.2417837	0.0614462	0.0000832
Inverse variance weighted	23	-0.1197685	0.0509418	0.0187188
Simple mode	23	-0.2416078	0.1347143	0.0866550
Weighted mode	23	-0.2493648	0.0889080	0.0103235

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	33.77829	21	0.0382684
Inverse variance weighted	37.83786	22	0.0191042

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0113194	0.0071251	0.1270804

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0014346	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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