Two sample MR report

Telomere_length against aseg lh volume CerebralWhiteMatter

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1754662	0.1296309	0.1902603
Weighted median	23	-0.0719725	0.0566610	0.2040025
Inverse variance weighted	23	-0.0267248	0.0527678	0.6125340
Simple mode	23	0.0852559	0.1024855	0.4144142
Weighted mode	23	-0.0326289	0.0691841	0.6418385

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	35.71391	21	0.0235387
Inverse variance weighted	40.59698	22	0.0091995

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0124145	0.0073264	0.1049538

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0012444	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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