Two sample MR report

Telomere_length against aseg lh volume Cerebellum-White-Matter

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1364122	0.1582016	0.3982800
Weighted median	23	0.0562604	0.0578544	0.3308280
Inverse variance weighted	23	0.0327475	0.0611241	0.5921280
Simple mode	23	0.0563023	0.1052450	0.5980406
Weighted mode	23	0.0616138	0.0589364	0.3071764

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	53.18878	21	0.0001292
Inverse variance weighted	54.47231	22	0.0001411

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0063649	0.0089411	0.4843776

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0016721	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8