Two sample MR report

Telomere_length against aseg lh volume Cerebellum-Cortex

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0605449	0.1268698	0.6381341
Weighted median	23	0.0605246	0.0579206	0.2960422
Inverse variance weighted	23	0.0507394	0.0484463	0.2949462
Simple mode	23	0.0670326	0.1005054	0.5117361
Weighted mode	23	0.0917934	0.0621578	0.1539066

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	34.20830	21	0.0344212
Inverse variance weighted	34.21978	22	0.0466533

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0006021	0.0071704	0.9338803

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010886	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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