Two sample MR report

Telomere_length against aseg lh volume Caudate

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1330160	0.1338342	0.3315930
Weighted median	23	-0.0860361	0.0582754	0.1398440
Inverse variance weighted	23	-0.0499360	0.0516466	0.3336040
Simple mode	23	-0.0971838	0.0972314	0.3284150
Weighted mode	23	-0.1252434	0.0649014	0.0666329

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	38.06624	21	0.0126602
Inverse variance weighted	38.89065	22	0.0145245

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0051011	0.007564	0.50742

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0012285	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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