Two sample MR report

Telomere_length against aseg lh volume Amygdala

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0764968	0.1046972	0.4730680
Weighted median	23	-0.0201722	0.0571773	0.7242374
Inverse variance weighted	23	0.0276616	0.0402162	0.4915652
Simple mode	23	-0.0758893	0.0979749	0.4468342
Weighted mode	23	-0.0316690	0.0631846	0.6211994

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	23.29515	21	0.3284457
Inverse variance weighted	23.58000	22	0.3696237

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0029985	0.0059172	0.6176201

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007299	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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