Two sample MR report

Telomere_length against aseg lh volume Accumbens-area

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0830498	0.1014647	0.4222578
Weighted median	23	-0.1370258	0.0553167	0.0132450
Inverse variance weighted	23	-0.0825472	0.0388451	0.0335835
Simple mode	23	-0.1793209	0.0836074	0.0432678
Weighted mode	23	-0.1578647	0.0670520	0.0278940

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	21.87937	21	0.4064900
Inverse variance weighted	21.87940	22	0.4671069

Test for directional horizontal pleiotropy

egger_intercept	se	pval
3.09e-05	0.0057345	0.9957571

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007998	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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