Two sample MR report

Telomere_length against aseg lh number HolesBeforeFixing

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0654133	0.1211779	0.5950050
Weighted median	23	0.0379487	0.0574405	0.5088301
Inverse variance weighted	23	0.0882514	0.0483098	0.0677327
Simple mode	23	0.0697222	0.1041524	0.5101898
Weighted mode	23	0.0430262	0.0617832	0.4934678

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	31.20655	21	0.0702885
Inverse variance weighted	34.02684	22	0.0488165

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0094349	0.0068487	0.1828225

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0011874	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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