Two sample MR report

Telomere_length against aseg lh intensity vessel

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0164867	0.0994058	0.8698594
Weighted median	23	0.1058366	0.0548939	0.0538524
Inverse variance weighted	23	0.1017900	0.0388452	0.0087826
Simple mode	23	0.1115084	0.0924160	0.2404045
Weighted mode	23	0.1053210	0.0661471	0.1256023

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	19.77518	21	0.5355391
Inverse variance weighted	21.44604	22	0.4933381

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0072622	0.0056182	0.2101856

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008579	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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