Two sample MR report

Telomere_length against aseg lh intensity choroid-plexus

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0494880	0.1199274	0.6840460
Weighted median	23	0.0747143	0.0591488	0.2065322
Inverse variance weighted	23	0.0262777	0.0462980	0.5703225
Simple mode	23	0.1016262	0.1134751	0.3801710
Weighted mode	23	0.1136216	0.0814424	0.1769066

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	30.56632	21	0.0811846
Inverse variance weighted	31.25196	22	0.0910738

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.004652	0.006778	0.5000098

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009608	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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