Two sample MR report

Telomere_length against aseg lh intensity VentralDC

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1764897	0.1254504	0.1741001
Weighted median	23	-0.0986657	0.0604986	0.1029169
Inverse variance weighted	23	-0.0831309	0.0533498	0.1191801
Simple mode	23	-0.0953793	0.1117342	0.4025112
Weighted mode	23	-0.0953793	0.0813420	0.2535086

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	33.44692	21	0.0414904
Inverse variance weighted	41.49769	22	0.0071863

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0159405	0.0070901	0.0354235

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0013962	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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