Two sample MR report

Telomere_length against aseg lh intensity Thalamus-Proper

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0823213	0.1100091	0.4625704
Weighted median	23	-0.1108863	0.0625055	0.0760589
Inverse variance weighted	23	-0.1042416	0.0452679	0.0212918
Simple mode	23	-0.0486430	0.1173411	0.6824906
Weighted mode	23	-0.1248216	0.0779877	0.1237444

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	25.71906	21	0.2173642
Inverse variance weighted	29.87620	22	0.1215045

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0114549	0.0062175	0.079585

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0011235	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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