Two sample MR report

Telomere_length against aseg lh intensity Putamen

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1553157	0.1261285	0.2317828
Weighted median	23	0.0435880	0.0583123	0.4547665
Inverse variance weighted	23	0.0389927	0.0492921	0.4289128
Simple mode	23	0.0342587	0.0996452	0.7342559
Weighted mode	23	0.0443798	0.0645960	0.4992389

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	33.80832	21	0.0379878
Inverse variance weighted	35.42444	22	0.0349646

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0071422	0.0071285	0.3277859

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0011039	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8