Two sample MR report

Telomere_length against aseg lh intensity Pallidum

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0970444	0.1347556	0.4793717
Weighted median	23	-0.0656116	0.0564093	0.2447747
Inverse variance weighted	23	-0.0528023	0.0516035	0.3061987
Simple mode	23	-0.1031010	0.0854069	0.2401846
Weighted mode	23	-0.0788921	0.0641702	0.2319019

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	38.59112	21	0.0109786
Inverse variance weighted	38.82490	22	0.0147778

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0027164	0.0076161	0.724895

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0012323	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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