Two sample MR report

Telomere_length against aseg lh intensity Lateral-Ventricle

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0055759	0.1235588	0.9644322
Weighted median	23	0.0561162	0.0616879	0.3629923
Inverse variance weighted	23	0.0229007	0.0472438	0.6278650
Simple mode	23	0.0880062	0.0969912	0.3740472
Weighted mode	23	0.0683432	0.0773385	0.3864187

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	32.44507	21	0.0527443
Inverse variance weighted	32.54192	22	0.0686148

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0017485	0.0069833	0.8047284

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009966	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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