Two sample MR report

Telomere_length against aseg lh intensity Inf-Lat-Vent

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0490597	0.1014647	0.6337334
Weighted median	23	-0.0561912	0.0548430	0.3055603
Inverse variance weighted	23	-0.0162000	0.0388523	0.6767040
Simple mode	23	0.2106247	0.1027957	0.0525786
Weighted mode	23	-0.0768876	0.0656937	0.2543648

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	21.87894	21	0.4065150
Inverse variance weighted	22.00790	22	0.4594173

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0020176	0.0057345	0.7284728

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006722	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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