Two sample MR report

Telomere_length against aseg lh intensity Hippocampus

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0036011	0.1284557	0.9778996
Weighted median	23	-0.0190317	0.0603295	0.7524111
Inverse variance weighted	23	-0.0021985	0.0490432	0.9642444
Simple mode	23	0.1894815	0.1244472	0.1421080
Weighted mode	23	-0.0359454	0.0695218	0.6102887

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	35.06785	21	0.0277548
Inverse variance weighted	35.06808	22	0.0381151

Test for directional horizontal pleiotropy

egger_intercept	se	pval
8.61e-05	0.00726	0.9906473

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010627	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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