Two sample MR report

Telomere_length against aseg lh intensity Cerebellum-White-Matter

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1909478	0.1148383	0.1112165
Weighted median	23	-0.0670567	0.0529243	0.2051444
Inverse variance weighted	23	-0.0103046	0.0467939	0.8257056
Simple mode	23	-0.0734010	0.0829233	0.3856392
Weighted mode	23	-0.0693993	0.0587522	0.2501273

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	28.02660	21	0.1393986
Inverse variance weighted	31.92411	22	0.0786992

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0110914	0.0064904	0.1022077

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009695	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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