Two sample MR report

Telomere_length against aseg lh intensity Cerebellum-Cortex

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2410414	0.1277793	0.0731483
Weighted median	23	-0.0165148	0.0584228	0.7774249
Inverse variance weighted	23	0.0132621	0.0539424	0.8057935
Simple mode	23	-0.0061570	0.0893390	0.9456782
Weighted mode	23	-0.0604923	0.0629108	0.3467228

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	34.69995	21	0.0304505
Inverse variance weighted	42.42426	22	0.0055513

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0156141	0.0072218	0.0423031

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.001289	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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