Two sample MR report

Telomere_length against aseg lh intensity Caudate

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0936339	0.1184223	0.4379708
Weighted median	23	0.0674817	0.0620280	0.2766295
Inverse variance weighted	23	0.0614092	0.0453065	0.1752851
Simple mode	23	-0.1153288	0.1144024	0.3243674
Weighted mode	23	0.0456711	0.0777031	0.5626761

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	29.80356	21	0.0960071
Inverse variance weighted	29.92759	22	0.1202350

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0019786	0.0066929	0.7704212

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009826	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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