Two sample MR report

Telomere_length against aseg lh intensity Amygdala

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0651296	0.1162996	0.5813943
Weighted median	23	-0.0778150	0.0633161	0.2190749
Inverse variance weighted	23	0.0473552	0.0444314	0.2865119
Simple mode	23	-0.0828518	0.1306111	0.5324009
Weighted mode	23	-0.0885283	0.0830558	0.2980326

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	28.74525	21	0.1202531
Inverse variance weighted	28.78299	22	0.1511616

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0010914	0.006573	0.8697176

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009172	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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