Two sample MR report

Telomere_length against aseg lh intensity Accumbens-area

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0506370	0.1079923	0.6439760
Weighted median	23	0.0611811	0.0598678	0.3068107
Inverse variance weighted	23	0.0330423	0.0412611	0.4232413
Simple mode	23	-0.0381676	0.1064913	0.7234527
Weighted mode	23	0.0325836	0.0733056	0.6610302

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	24.78448	21	0.2566190
Inverse variance weighted	24.82146	22	0.3056889

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0010803	0.0061035	0.8612046

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007741	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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