Two sample MR report

Telomere_length against aseg global volume-ratio MaskVol-to-eTIV

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0940621	0.1253580	0.4613704
Weighted median	23	-0.0292041	0.0630487	0.6432215
Inverse variance weighted	23	-0.0228295	0.0490158	0.6413886
Simple mode	23	-0.0785752	0.1156820	0.5040737
Weighted mode	23	-0.0753513	0.0893980	0.4083694

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	33.39734	21	0.0419927
Inverse variance weighted	35.02934	22	0.0384725

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0071771	0.0070849	0.3225854

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010719	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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