Two sample MR report

Telomere_length against aseg global volume-ratio BrainSegVol-to-eTIV

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0987391	0.1204401	0.4215273
Weighted median	23	-0.1872555	0.0616197	0.0023745
Inverse variance weighted	23	-0.0829250	0.0460053	0.0714656
Simple mode	23	-0.1925137	0.1287995	0.1492052
Weighted mode	23	-0.1925137	0.0811040	0.0267667

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	30.82918	21	0.0765482
Inverse variance weighted	30.85905	22	0.0990359

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.000971	0.0068071	0.8879302

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010732	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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