Two sample MR report

Telomere_length against aseg global volume non-WM-hypointensities

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1643432	0.0994058	0.1131516
Weighted median	23	0.0176467	0.0538386	0.7430850
Inverse variance weighted	23	0.0051022	0.0388455	0.8955024
Simple mode	23	-0.0185561	0.0816360	0.8222876
Weighted mode	23	0.0078434	0.0616310	0.8998872

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	16.99135	21	0.7116303
Inverse variance weighted	20.02003	22	0.5817867

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0097774	0.0056182	0.09644

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006072	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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