Two sample MR report

Telomere_length against aseg global volume WM-hypointensities

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1774581	0.1227908	0.1631579
Weighted median	23	0.0981194	0.0555881	0.0775442
Inverse variance weighted	23	0.0986005	0.0474203	0.0375907
Simple mode	23	-0.0642398	0.0917882	0.4913437
Weighted mode	23	0.0848777	0.0665931	0.2157595

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	32.04305	21	0.0579652
Inverse variance weighted	32.78579	22	0.0649513

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0048418	0.0069399	0.4930268

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0011884	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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