Two sample MR report

Telomere_length against aseg global volume VentricleChoroid

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0280045	0.1149963	0.8099615
Weighted median	23	0.0679485	0.0554988	0.2208303
Inverse variance weighted	23	-0.0202636	0.0439104	0.6444570
Simple mode	23	0.0606397	0.0903656	0.5091745
Weighted mode	23	0.0573301	0.0623325	0.3676811

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	28.10412	21	0.1372231
Inverse variance weighted	28.11127	22	0.1720227

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0004753	0.0064993	0.9423952

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.00086	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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