Two sample MR report

Telomere_length against aseg global volume TotalGray

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2108544	0.1177892	0.0878683
Weighted median	23	-0.1950024	0.0592901	0.0010056
Inverse variance weighted	23	-0.0706125	0.0467280	0.1307534
Simple mode	23	-0.2057073	0.1167934	0.0920828
Weighted mode	23	-0.1978418	0.0804306	0.0222310

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	29.48673	21	0.1027978
Inverse variance weighted	31.83592	22	0.0802368

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0086109	0.0066572	0.209897

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010648	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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