Two sample MR report

Telomere_length against aseg global volume SupraTentorialNotVent

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0133399	0.1119808	0.9063075
Weighted median	23	-0.1576526	0.0597011	0.0082736
Inverse variance weighted	23	-0.0778838	0.0431512	0.0710895
Simple mode	23	-0.1753771	0.1140214	0.1382822
Weighted mode	23	-0.2041833	0.0883264	0.0305435

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	26.65120	21	0.1826988
Inverse variance weighted	27.14881	22	0.2056289

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0039631	0.006329	0.5379471

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009445	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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